After normalized to organ CFU burden of infection, IL-6, GM-CSF, IFN-γ and IL-17 in the kidneys of mnn10 mutant infected mice were markedly higher than mice infected with parental or revertant strains (P < 0.01, Fig 4D) (the actual cytokine values were shown in S7 Fig). The gene discussed is IFNG; the disease is infection.