In order to determine whether transcriptional regulation by Ap4A is confined to relatively few genes or is more widespread, we have analysed the transcriptome of a knockout derivative of the KBM-7 chronic myeloid leukaemia (CML) cell line [37] in which the intracellular level of Ap4A has been increased 175-fold by disruption of the NUDT2 gene (KBM-7-NuKO, referred to hereafter as NuKO). The gene discussed is NUDT2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.