SGPP2 and cancer: Finally, type II transglutaminase (TGM2) is up-regulated 10-fold in NuKO cells and may have an important role in maintaining survival, invasion and the metastatic behavior of a variety of tumors and cancer stem cells [126] while sphingosine-1-phosphate phosphatase 2 (SGPP2, up 63-fold) may be a target for the tumor suppressor miRNA-31 [127].