NR4A1 binds and inactivates p53 (Figure 1B) and knockdown of NR4A1 or treatment with NR4A1 antagonists results in p53-dependent induction of sestrin 2, an upstream regulator of AMPKα in lung and colon cancer cells [12, 16]. This evidence concerns the gene NR4A1 and malignant colon neoplasm.