The function and mechanism of action of NR4A1 in cancer cells is complex; transgenic mice in which both NR4A1 and NR4A3 (Nurr1) have been knocked out rapidly develop an acute myeloid leukemia (AML) type of leukemia and there is evidence that NR4A1 is a tumor suppressor for AML [21, 22]. This evidence concerns the gene NR4A2 and neoplasm.