Nevertheless, we note that FRA1-promotion of cell migration likely involves other AP-1 target genes such as MMPs and adenosine receptor A2B (ADORA2B) as described in breast cancer [52, 53], uPA in colon carcinoma [54], receptor tyrosine kinase AXL in bladder cancer [28], and CD44 and c-Met in mesothelioma [55]. Here, ADORA2B is linked to colon carcinoma.