We found that the mean normalized z-scores of mRNA expression were significantly reduced for both MCT1 (Figure 6A, 0.22 vs. −0.21, p<0.05) and MCT4 (Figure 6B, 0.25 vs. −0.15, p<0.005) in mutant IDH1 glioma samples (n=218) compared to wild-type IDH1 low-grade glioma (n=68). This evidence concerns the gene SLC16A1 and central nervous system cancer.