Overall, GP IIb/IIIa inhibitors, administered PO or IV, increase the rate of thrombocytopenia (RR = 1.62; 95% CI 1.48–1.78) and severe thrombocytopenia (RR = 3.52; 95% CI 2.87–4.30). The gene discussed is ITGA2B; the disease is Thrombocytopenia.