HOTAIR and cancer: LncRNA PCAT-1 which is a target of histone-modifying PRC2 complex bearing both oncogenic and tumor-suppressive features was found to promote cell proliferation [37]; antisense noncoding RNA in the INK4 locus (ANRIL; also known as CDKN2BAS) is upregulated in prostate cancer and implicated in tumor suppression [38]; HOTAIR upregulation is associated with poor prognosis in pancreatic [39], colorectal [40], liver [41], gastrointestinal [42], and breast [43] cancers and likely also contributes to increased metastasis [43] of these cancer types.