Y. Tian et al. in their paper, “Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes,” reported that secretion of Factor D (the rate limiting enzyme of the complement alternative implicated in the pathogenesis of AMD) was significantly decreased following lutein supplementation to cultured human adipocytes. The gene discussed is LIF; the disease is age-related macular degeneration.