It has been widely reported that the hepatocyte growth factor (HGF) displays a response that regulates the redox homeostasis by different mechanisms and diverse liver diseases such as the expression of antioxidant proteins, or repression of prooxidant systems in alcoholic liver disease [5–8], in drug-induced liver injury [9, 10], or by the action of cytotoxic growth factors like transforming growth factor beta (TGF-β) [11]; even more, HGF can suppress the activity and expression of one of the main ROS generator systems, the NADPH oxidase [12]. The gene discussed is HGF; the disease is liver disorder.