Modulation of the UPS has also been observed and, in particular, the expression of the IFN-γ inducible components of the UPS such as PA28α/β and the i-subunits β1i/LMP2 and β5i/LMP7 were found to be altered in tumor cells, affecting both the quantity and in certain cases also the quality of the generated epitopes20, 21, 22. Here, IFNG is linked to neoplasm.