CXCR4 and cancer: While specific receptors of CXCL14 have not been identified, a recent study showed that CXCL14 binds to CXCR4 (chemokine [C-X-C motif] receptor 4) as a decoy ligand, inhibiting CXCL12 signal transduction through CXCR4 (21), an important signaling pathway for cell growth, angiogenesis, and metastasis in many cancers.