Importantly, restoration of murine Cxcl14 expression in HPV-positive mouse oropharyngeal epithelial (MOE) cells increases NK, CD4+ T, and CD8+ T cell infiltration into the tumor-draining lymph nodes (TDLNs) and results in significant clearance of implanted HPV-positive HNC cells in immunocompetent syngeneic mice. Here, CXCL14 is linked to neoplasm.