Standard surrogate indexes were calculated from fasting blood glucose and plasma insulin concentrations as follows: quantitative insulin sensitivity check index QUICKI = 1/(log(I0) + log(G0)), where I0 is fasting insulin (μU/ml) and G0 is fasting glucose (mg/dl); and homeostatic model assessment of insulin resistance HOMA-IR = (G0 * I0)/22.5, with fasting glucose expressed as mmol/l and fasting insulin expressed as μU/ml. This evidence concerns the gene INS and Insulin resistance.