GABRA1 and Bardet-Biedl syndrome: For example, downregulation of the G protein genes gngt1, gng7, and gng8, as well as the GABA receptor genes gabrb2, gabrb3, gabra1, gabra2, gabra3, and gabrg2 in BBS may be driving the cognitive deficits characteristic of the disorder, as these genes were found in the majority of the downregulated neuronal system pathways.