To identify differentially expressed genes in Alström Syndrome (Alms) and Bardet-Biedl Syndrome (BBS), we generated zebrafish models of either syndrome using splice blocking morpholinos (MOs) targeting either alms1 or bbs1 transcripts that were previously validated to suppress protein production without introduction of off-target effects [9]. The gene discussed is ALMS1; the disease is Alstrom syndrome.