In detail, Armeanu and colleagues demonstrated an enhancement of cell-surface expression of MICA/B in HepG2 and Hep3B hepatoma cells with no alterations of ULBP1-3 levels upon stimulation with the HDAC inhibitor valproic acid (VPA), which led to an enhanced NK cell-mediated killing [23]. This evidence concerns the gene MICA and hepatocellular carcinoma.