CRBN and Miyoshi myopathy: It is clear that the treatment of CRBN-low MM cells, such as My5.LV or MM1.S.Res (Fig. 1a and b), with 10 μM lenalidomide did not induce apoptosis (Fig. 8b), whereas the treatment of CRBN-high MM cells, such as My5.CRBN, JJN3 or MM1.S (Fig. 1a and b), with 10 μM lenalidomide significantly induced apoptosis (Fig. 8b).