CRBN and Miyoshi myopathy: In order to better understand the response of MM cells to IMiD, lentiviral particle harboring human CRBN cDNA infected My5 cells (My5.CRBN.His) and lentivirus vector (as a control) infected My5 cells (My5.LV) were treated with various concentrations of lenalidomide for several days and the survival of the cells was monitored by 3–(4,5-dimethylthiazol-2-yl)–2,5-diphenyltetrazolium bromide dye (MTT) assay.