In order to confirm whether the un-tagged proteins could also be co-IPed with mouse monoclonal antibody against CRBN, the cell lysates from MM cell expressing higher level of CRBN (JJN3 in Fig. 1a and b) or lower level of CRBN (My5.LV in Fig. 1a and b) were used to do Co-IP with 2F11G5. This evidence concerns the gene CRBN and Miyoshi myopathy.