PBRM1 and schizophrenia: These PPIs are of particular interest since genetic association studies have previously implicated YWHAE, YWHAH, and YWHAZ with schizophrenia and bipolar disorder [52–55] and the PBRM1 locus has surpassed genome-wide significance in both schizophrenia and bipolar disorder GWASs [4, 56–58].