Several studies have implicated 14-3-3 genes with schizophrenia and bipolar disorder [52–55, 68], YWHAE and YWHAZ interact with disrupted in schizophrenia 1 (DISC1) [69], and Ywhae+/– and Ywhaz–/– mice have been shown to display neurodevelopmental and schizophrenia-associated phenotypes [70, 71]. Here, YWHAZ is linked to bipolar disorder.