Furthermore, in the controls, serum level of insulin and insulin resistance in the women with the INSR "pp" genotype compared with those with the "PP + Pp" genotypes were lower and the difference remained significant after adjustment for age and BMI (n= 18, n= 17, respectively; insulin 9.28 ± 1.33 versus 21.05 ± 1.23, p= 0.036; HoMA- IR 2.15 ± 1.35 versus 5.30 ± 1.26, p= 0.041). This evidence concerns the gene INS and Insulin resistance.