In this regard, drugs used in PCOS treatment is aromatase inhibitors (AIs) like letrozol, which is co-administered with gonodotrapins to improve ovulation and clomiphene citrate (CC), which is the first treatment to stimulate ovulation of PCOS patients who are undergoing Intrauterine Insemination (IUI). This evidence concerns the gene CYP19A1 and polycystic ovary syndrome.