Importantly, radiation has been shown to induce an immunogenic cell death, characterized by three molecular signals that promote uptake of dying cells by DCs, cross-presentation of the tumor-derived Ags to T cells and activation of antitumor T cells, exposure of calreticulin on the tumor cell surface, release of high-mobility group protein B1 (HMGB1), and release of ATP.86 This evidence concerns the gene HMGB1 and neoplasm.