While the increased Fn at the MTJ of laminin gamma1 mutants did not completely rescue muscle morphogenesis in these mutants, just as the increased integrin alpha7 expression observed in humans with DMD does not prevent muscle atrophy, one key experiment shows that reducing Fn downregulation in laminin mutants did have a positive effect on slow-twitch muscle fibers. This evidence concerns the gene FN1 and Duchenne muscular dystrophy.