Apart from its conventional role in infiltration, modulating adhesion and migration of neoplastic B cells36, CD53 is also known to be associated with glioblastoma, ovarian, breast, colon, kidney, lung, uterine and rectum cancer31 wherein its expression correlates with radioresistance, matrix degradation, inflammation, regulating apoptosis to trigger tumor cell survival37, 38 and results in poor patient prognosis39, 40. The gene discussed is CD53; the disease is digestive system cancer.