For instance autoantibodies against CTAG1 and CTAG2 or against MAGEA3 and MAGEA4 are frequently found together and the combination of such a pair of autoantibodies would not result in a large gain of sensitivity, while for example the addition of anti-TP53 to an autoantibody against a cancer-germline antigen could increase sensitivity substantially. The gene discussed is MAGEA3; the disease is cancer.