Conversely, IP6K2 also enhances p53-mediated apoptosis in cancer cells so that the loss of IP6K2 results in reduced apoptosis [19], [20], and IP6K2 knockout mice are more susceptible to 4-nitroquinoline-1-oxide (4NQO) induced aerodigestive tract carcinoma [21]. This evidence concerns the gene IP6K2 and cancer.