TNFSF10 and neoplasm: Moreover, continuous exposure to sublethal concentrations of TRAIL induces an NFkB-dependent increase in miR-21, miR-30c and miR-100, which downregulates expression of caspase 8, caspase 3, TRAF7 and Foxo3a, resulting in acquired resistance to TRAIL and the development of more aggressive tumours (Jeon et al, 2015).