Moreover, continuous exposure to sublethal concentrations of TRAIL induces an NFkB-dependent increase in miR-21, miR-30c and miR-100, which downregulates expression of caspase 8, caspase 3, TRAF7 and Foxo3a, resulting in acquired resistance to TRAIL and the development of more aggressive tumours (Jeon et al, 2015). This evidence concerns the gene FOXO3 and neoplasm.