Additionally, because of the critical immunosuppressive role of TGFβ1 (Shull et al. 1992; Kulkarni et al. 1993; Yaswen et al. 1996), pan-TGFβ blockade can lead to excessive autoimmunity and inflammation, which could be highly deleterious in a fibrotic organ with limited functional reserve. Here, TGFB1 is linked to Autoimmunity.