TARDBP and early-onset autosomal dominant Alzheimer disease: It is believed that abnormal phosphorylation of TDP-43 at the Ser 409/410 is a critical step in FTLD-TDP and other neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) [8, 33] Alzheimer’s disease (AD) [34], and Parkinson’s disease (PD).