TARDBP and neuroblastoma: To validate the results obtained in non-neuronal cells from FTLD-TDP patients, we tested the effects of IGS-2.7 and IGS-3.27 in a neuronal cell model of induced TDP-43 phosphorylation by ethacrynic acid (EA) treatment [32] Human neuroblastoma SH-SY5Y cells were preincubated with the CK-1δ inhibitors, and then treated with 20 μM EA for 12 h.