Under fed, but not under fasted conditions, 32-week-old C2αD1268A/WT males displayed hyperglycaemia (Fig. 5a, b) and hyperinsulinaemia (Fig. 5c, d), with reduced glucose clearance, despite an observed elevated insulin secretion during the glucose tolerance test (GTT) (Fig. 5e, f). Here, INS is linked to Hyperglycemia.