LRP6 and familial pancreatic carcinoma: These include the colorectal, gastric, ovarian and pancreatic cancers that harbour inactivating mutations in RNF43 (refs 65, 66, 67, 68, 69, 70), a negative Wnt feedback regulator that promotes degradation of the Wnt co-receptors Frizzled and LRP6 (refs 70, 71, 72).