Most imaging genetic studies in PTSS and PTSD focused on polymorphisms in coding regions of candidate genes.9, 12, 13 However, the great majority of genetic polymorphisms are located in noncoding regulatory regions.14 One of these is the single-nucleotide polymorphism (SNP rs17228616) C2098A substitution in the ‘seed' domain of miRNA-608 binding site, at the 3′-untranslated region of the acetylcholinesterase (AChE) gene. The gene discussed is ACHE; the disease is post-traumatic stress disorder.