ACHE and Anxiety: The coding regions of the genome account for less than 2% of the entire human DNA,42 and numerous noncoding genomic domains contribute to individual differences in reactivity to neural diseases, including threat and its regulation.43, 44 Nevertheless, most anxiety-related imaging genetic studies focus on those simple-to-explain polymorphisms in the coding regions of candidate genes.9 In the present study, we selected the rs17228616 SNP in the noncoding region of the AChE gene to investigate gene–environment brain interactions as those are reflected in PTSS.