This accords with recent genome-wide association studies, concluding that the genetic architecture of PTSD may be determined by many SNPs with small effects that are not directly related to the cholinergic pathway.48, 49 For the AChE gene, this outcome plausibly reflects the exceedingly high G, C content that complicates genome-wide association study data collection. This evidence concerns the gene ACHE and post-traumatic stress disorder.