ACHE and Cognitive impairment: We expected that this would be manifested by enhanced neural response of the threat circuit, including the amygdala which is rich in both GABAergic synapses and AChE.32 In addition, animal studies have demonstrated involvement of inherited tendencies of AChE increases in response to stress,33 miRNA suppression of brain AChE (by miRNA-132) which limits stress-induced cognitive impairments,34 and CDC42 suppression leading to anxiogenic reaction.15 Therefore, we predicted modulated PTSS reactions in individuals with the minor allele of the rs17228616 SNP.