In addition to the well‐known role of these proteins in promoting the metabolic reprogramming of cancer cells, some HIF‐1α‐induced glycolytic isoforms also participate in survival processes, including inhibition of apoptosis (i.e., HKII) (Sato‐Tadano et al, 2013) and promotion of cell migration (i.e., G6PI) (Torimura et al, 2001). The gene discussed is HIF1A; the disease is cancer.