In this respect, rAAV were used for hepatic delivery in adult and newborn mice of ZFNs to intron 1 of the factor 9 gene (F9) and as DNA donor an acceptor splicing sequence and the cDNA of exons 2–8 to obtain production of factor IX in a humanized murine model of hemophilia B (Li et al, 2011). This evidence concerns the gene F9 and hemophilia B.