In the UMD-FBN1 mutations database (http://www.umd.be/), a total of 1,318 different FBN1 mutations for MFS have been included to date, of which only 59 (4.8 %) including 37 missense mutations (2.8 %) are associated with nMFS. This evidence concerns the gene FBN1 and Marfan syndrome.