Our findings indicate that targeting MEK1/2 using specific drugs (such as Selumetinib—AZD6244 and PD184352 used here) may abrogate the harmful invasive migration and metastasis in certain contexts, particular for patients with tumours that harbour gain-of-function p53 mutation or which exhibit an upregulation in α5β1 expression. Here, TP53 is linked to neoplasm.