Furthermore, Rab-coupling protein (RCP) dependent endocytic recycling of the fibronectin (FN) receptor α5β1 integrin promotes formation of filopodial actin-spike protrusions to drive invasive migration in FN rich 3D-ECM and in vivo in response to inhibition of αvβ3 integrin or expression of gain-of-function (GOF) mutant p53 in cancer cells [20,21]. Here, TP53 is linked to cancer.