Interestingly, HDAC1-3 upregulation reduces the expression of miR-449a in HCC cell lines, whereas miR-449a overexpression reduces the expression of its target c-MET, decreases the phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), and inhibits the proliferation of HCC cells18. The gene discussed is HDAC1; the disease is hepatocellular carcinoma.