Treatment with 4 μM of the PI3K inhibitor wortmannin for 24 h resulted in about 60% apoptosis in AD-iPSCs, whereas the B-RAF inhibitor L-779,450, the death ligand TRAIL, the IKK inhibitor BMS-345541 and the Aurora kinase A inhibitor MLN-8237 had, if any, marginal effects (Fig 6A and 6B). This evidence concerns the gene BRAF and Alzheimer disease.