CA4 and breast carcinoma: All synthesized 12 derivatives were evaluated for their inhibitory effect of growth of six different human cancer cell lines (human liver carcinoma cell line HepG2, human epithelial cervical cancer cell line Hela, human breast carcinoma cell line MCF-7, carcinomic human alveolar basal epithelial cell line A549, human colorectal cancer cell line HT-29 and oral cancar SSC-4 cells), in comparison with the reference CA-4.