VEGFA and neoplasm: Sorafenib is known to inhibit tumor growth by a dual mechanism that involves either a direct effect on the tumor by inhibiting the proliferation in several signaling pathways and/or on an indirect effect, preventing tumor angiogenesis by means of the inhibition of VEGF and other signaling pathways (11,12) (see also FDA prescription information: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021923s016lbl.pdf).