In contrast, no effect on AKT1, PTN, CAV1, and PI3 K was seen in the experiments in which fully differentiated 3T3‐L1 cells were treated with 500 μM CML for 30, 60, or 90 min (Fig. 4). The gene discussed is PTN; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.