In our study, we confirmed that IFI16 was overexpressed in the epidermis of psoriatic patients, and in vivo evidences suggested that knocking down p204 in imiquimod-treated mice successfully improved epidermal hyperplasia and alleviated skin inflammation, which demonstrated that IFI16 contributes to psoriasis development and may be targeted in psoriasis treatment. Here, IFI16 is linked to dermatitis.