TNF and psoriasis: We found that besides cytosolic dsDNA, the psoriasis-related cytokines IFN-γ, TNF-α, IL-17 and IL-22 also induced the up-regulation of IFI16 in keratinocytes via STAT3 signaling, which is partly consistent with a recent study demonstrating that TNF-α and IL-1β enhance IFI16 expression induced by cytosolic dsDNA in human primary keratinocytes11, 28, 29.