IFI16 and psoriasis: In our study, we confirmed that IFI16 was overexpressed in the epidermis of psoriatic patients, and in vivo evidences suggested that knocking down p204 in imiquimod-treated mice successfully improved epidermal hyperplasia and alleviated skin inflammation, which demonstrated that IFI16 contributes to psoriasis development and may be targeted in psoriasis treatment.