Two patients (out of 14 patients from this HH cohort with functional hypogonadism) were identified as heterozygous for a shared loss‐of‐function mutation in IGSF10 (NM_178822: c.7353_7354insATCA: (rs570110855) p.L2452 fs). The gene discussed is IGSF10; the disease is hypogonadism.