INS and obesity due to melanocortin 4 receptor deficiency: While there is no doubt that insulin is an important mediator of metabolic control in the prandial state (Boucher et al, 2014), insulin resistance likely represents a physiological feedback mechanism to actually retard the development of obesity‐driven complications (Hoehn et al, 2009), prompting speculation that “insulin sensitisation” may be a flawed strategy (Connor et al, 2015).