In addition, although we could show mild differential regulation in perigonadal white adipose tissue (pgWAT; Appendix Fig S1B–D), brown adipose tissue (BAT; Appendix Fig S1E–G) and gastrocnemius complex skeletal muscle (GCM; Appendix Fig S1H–J) of Gadd45a (Appendix Fig S1B, E and H), Gadd45b (Appendix Fig S1C, F and I) and Gadd45g (Appendix Fig S1D, G and J) between fed and fasted states comparing lean and obese/T2D mice, none of these regulations were as striking as observed with the liver Gadd45b (Fig 2). This evidence concerns the gene GADD45B and type 2 diabetes mellitus.