Interestingly, in lung cancer, tumor buds exhibited decreased nuclear levels of geminin, a key cell cycle regulator as compared to the main tumor mass [62], which might offer an alternative explanation for the co-occurrence of decreased E-cadherin and β-catenin levels with a non-proliferative state in budding cells (see [62] and the references therein). This evidence concerns the gene CDH1 and lung carcinoma.