Consistently, the membranous localization of E-cadherin, the key cell-cell adhesion molecule in epithelial cells, is relatively low in tumor buds of CRC [10], esophageal cancer [51], PDAC [53,54], head and neck cancer [58,59,67], lung cancer [60], and invasive ductal breast cancer [63]. Here, CDH1 is linked to lung carcinoma.