Expression of CXCL10 in stage II and/or III CRC was reported to be an independent good prognostic factor regarding recurrence [65,66], whereas another recent study shows that co-expression of CXCL10 and CXCR3 in CRC is a predictor of metastatic recurrence and poor prognosis [67]. This evidence concerns the gene CXCR3 and colorectal carcinoma.