In host-targeted investigations, it has been reported recently that deletion of CXCR3 in all host cells significantly decreased lung metastasis of breast cancer by decreased expression of IL-4, IL-10, inducible nitric oxide synthase (iNOs) and arginase-1 (Arg1) in myeloid cells with an increased T cell response [64]. The gene discussed is ARG1; the disease is breast cancer.