It was also reported that loss of TGF-β signaling promoted CXCL1 and CXCL5 secretion, which increased migration of CD11b+ Gr-1+ MDSC to the tumor tissues, and played indirect roles in increasing the number of T helper 17 (Th17) cells which have a pro-tumorigenic effect [74]. This evidence concerns the gene ITGAM and neoplasm.