ELANE and neoplasm: We observed significant deposition of NETs in tumour sections, as extracellular colocalization of neutrophil elastase with citrullinated H3 (Fig 1Ai and 1Aii) and neutrophil elastase with myeloperoxidase (Fig 1Aiii) in confocal microscopy, in contrast to their absence in normal intestine sections of the same patients.