GIP and Insulin resistance: A decreased expression of the GIP receptor (GIPr) in subcutaneous adipose tissue has been shown to be associated with signs of insulin resistance in non-diabetic women with central obesity.23 Another study indicated that GIPr expression in subcutaneous adipose tissue is inversely associated with BMI.24 A recent study demonstrated a defective GIP/GIPr signaling axis in adipose tissue in obese subjects.25 This defect was characterized by decreased GIPr expression in the subcutaneous adipose tissue, showing an inverse relationship with insulin resistance.