Moreover, a recent study, including obese volunteers, endurance‐trained athletes, and individuals with type 2 diabetes, found that muscle ceramide concentration increased during acute exercise and then decreased after the recovery to levels significantly lower than their baseline values, and the authors suggested that the change in muscle ceramides may promote insulin‐sensitizing effects of acute exercise (Bergman et al., 2016). This evidence concerns the gene INS and type 2 diabetes mellitus.