TIMP3 and neoplasm: In addition, miR-20a promotes epithelial to mesenchymal transition (EMT), a key step in tumor metastasis, through targeting the tumor suppressor gene (tissue inhibitor matrix metalloproteinase 3 (TIMP3)); negative regulator of matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) that mediated extracellular matrix (ECM) degradation [15].