Likewise, in the U373-MG glioblastoma cells that showed constitutive NF-κB activity and high levels of TRIP6, depletion of TRIP6 by Cas9/sgRNA also attenuated the basal and LPA-stimulated IκBα phosphorylation and JNK activation (Supplementary Figure S3a). This evidence concerns the gene TRIP6 and glioblastoma.