It may be noteworthy that the levels of CYLD were frequently, if not always, found to be slightly higher in U373-MG cells (Supplementary Figure S3b) or SKOV-3 cells (Figure 3i) stably expressing Cas9/TRIP6 sgRNA, and this might partly contribute to the effect of TRIP6 depletion on the reduced NF-κB activity in these cancer cells. Here, CYLD is linked to cancer.