TRAF6 and cancer: IL-6 and IL-8 can further activate STAT3, which has been shown to promote apoptotic resistance and contribute to poor prognosis of cancer patients [31, 32] Although TRAF6 is known to mediate LPA-stimulated NF-κB activation [2], it is not clear whether TRAF6 plays a particular role in the LPA2 receptor signaling.