In line with these data, we observed a significant cytotoxic increase when HCC cells were co-incubated with 5-AZA and vitamin C which is paralleled by an increased inhibition of cell proliferation, a decreased Snail expression, and an upregulation of the cell division kinase 2 (CDK-2) inhibitor; P21. This evidence concerns the gene CDK2 and hepatocellular carcinoma.