RELN and neurodevelopmental disorder: In line with previous data supporting genome-wide epigenetic and transcriptomic abnormalities in ASD brains [37, 42], our results zoom into the RELN gene which is relevant, on the one hand, to physiological neurodevelopment and post-natal synaptic management, as well as, on the other hand, to the pathological neurodevelopment underlying several neurodevelopmental disorders, including ASD [17].